In the present study rats were divided into five groups. Rats of group I (normal control) administered with distilled water only, group II (disease control) treated with distilled water, group III (standard group) treated with ranitidine (50 mg/kg). Group IV and V served as test groups and were administered with Caesalpinia crista extract (CE) in the dose of 250 mg/ kg and 500 mg/ kg orally respectively. All the groups except normal control were administered with cysteamine hydrochloride (CYH) (280 mg/kg) orally. All animals were fasted for the 48 hour before induction of ulcer. During fasting condition, there was free access to water. After 48 hour, cysteamine – HCl is administered three times on day 1st in the dose of 280 mg/kg orally. Standard and the test drugs were administered 30 min prior to the cysteamine treatment. These standard and test drug treatments were continued on 2nd and 3rd day. Rats were sacrificed on 3rd day. All treatments were administered orally. Parameters like ulcer score, ulcer index and % ulcer protection were estimated for evaluation of anti ulcer activity. The aqueous extract of Caesalpinia crista seeds decreased the ulcer score and ulcer index, where as it increased % ulcer protection. These findings suggest that Caesalpinia crista seeds may be effective in preventing duodenal ulcer.
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